What is a notable characteristic of naltrexone compared to opioid agonists?

Naltrexone is known for its unique mechanism of action as an opioid antagonist. Unlike opioid agonists that activate the mu-opioid receptors to produce effects such as pain relief and euphoria, naltrexone blocks these receptors. This blocking effect is critical in the treatment of opioid dependence, as it prevents the euphoric effects typically associated with opioids, thereby reducing cravings and the potential for relapse.

The inability of naltrexone to activate the mu-opioid receptor distinguishes it from traditional opioid medications. This characteristic allows it to help individuals who are recovering from opioid addiction by mitigating the reinforcing effects of opioids without providing the same effects that lead to further misuse.