What percentage range indicates the availability of methadone when administered?

The correct percentage range for the availability of methadone when administered is significant because it reflects how effectively the drug can be absorbed and utilized by the body after administration. In this case, a 70-80% availability indicates that when methadone is given, a substantial portion of the drug is available to exert its therapeutic effects.

This range is considered optimal for a medication like methadone, which is often used for pain management and in addiction treatment. A higher availability suggests that the drug can be effective at lower doses, potentially minimizing side effects and reducing the risk of overdose, which is particularly important in the context of opioid use.

In contrast, the other ranges may imply either suboptimal absorption or an unrealistic expectation of drug availability. For instance, percentages lower than 70% would suggest reduced efficacy, while ranges that are too high, such as 90-100%, may indicate complete absorption or bioavailability, which is not typical for many medications due to factors such as metabolic processing and first-pass effect. Thus, the 70-80% range represents a clinically valid expectation for methadone’s availability in medical practice.