Which opioid medication combination is known for its abuse potential?

The combination of oxycodone and naloxone is particularly noteworthy due to its design aimed at addressing abuse potential. Oxycodone is an opioid that has significant analgesic properties and a well-documented risk of misuse and addiction. To mitigate this risk, naloxone is included in the formulation. Naloxone is an opioid antagonist that can counteract the effects of opioids and is intended to block the euphoric high that may lead to abuse.

In this combination, the presence of naloxone is specifically meant to deter misuse by triggering withdrawal symptoms in individuals who attempt to misuse the oxycodone by injection. Although this combination does not eliminate the potential for abuse entirely, it was developed with a focus on reducing that risk as much as possible while still providing pain relief.

Other combinations listed, while they may contain opioids, do not incorporate abuse-deterring mechanisms like naloxone does, making them more straightforwardly associated with higher abuse potential.